110 Squadron also has the unofficial nickname "Hakrav Haftsatsa" - The Multi Role Fighter Squadron.

Formed in 1953, this unit received a further 14 ex-Royal Navy Mosquito TR.33s in early 1955. 110 sqn was the only user of this variant, used in the bomber rather than attack role. The 13 remaining Mosquitos were placed in storage around June/July 1956 but reactivated on 25 October 1956 at Ramat David.

By the time of the Suez campaign in October 1956, the Mosquito was being phased out from IDF/AF service, with 110 sqn being the last operator. Nevertheless, the unit was involved in providing close air support for ground forces; including the capture of Rafah in the Gaza strip, and attacks on an Egyptian armoured column heading for El Arish in northern Sinai - successfully stopping it.

The unit moved into the jet age with the arrival of the Vautour IIA (single seat attack) in mid 1957 and the Vautour IIB (two seat bomber) a year later. Vautour strength was supplemented by Vautour IIN's (two seat night fighter) from 119 sqn in March or August 1963, (sources differ). The IIN's had their radar replaced by ballast for the attack role.

In 1962 the squadron received about a dozen Meteors T.7s from 117 squadron, for twin jet conversion training and target towing duties. In 1964 the Meteor F.8/FR.9s of 107 sqn were also added. The last surviving Meteors were finally retired in early 1970.

The Vautours were first used operationally on 13 November 1964, in a large scale air strike on a Syrian position which had been firing on an Israeli kibbutz. On the first day of the Six Day War, early on 5 June 1967, flights of IIA's, with IIN's acting as navigation leaders, hit the Egyptian airbases at Abu Sueir and Beni Sueif. One aircraft was lost over Syria in further raids that day, but an Iraqi AF Hunter was shot down by a Vautour during a raid on H-3 airfield the next day. In all, five aircraft out of a total strength of twenty were shot down during the war. As the war progressed missions switched to close air support on the Syrian front. Only ten aircraft remained by August 1970.

This unit received the A-4H version of the Skyhawk (from 1971, becoming the fifth A-4 sqn); and subsequently a number of ex-USN A-4Es to replace Yom Kippur War losses of the H variant. It later re-equipped with the N variant. A-4's flew many attack missions in support of the invasion of Lebanon in June/July 1982, during which at least two Skyhawks were lost.

The A-4Ns eventually went to 115 and 102 sqns when, in 1981, the squadron was the second unit to convert to the F-16A/B. This squadron's F-16s reportedly had special Israeli Elta 2021B radars. Four aircraft and pilots from 110 sqn flew in the Osirak Reactor raid of June 1981. The unit upgraded to the F-16C/D version in 1987/88.